Synthesis of substituted 2-phenylhistamines via a microwave promoted Suzuki coupling
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چکیده
منابع مشابه
Solution-phase synthesis of a thiazoyl-substituted indolyl library via Suzuki cross-coupling.
The application of parallel synthesis to generate combinatorial libraries as an efficient means of creating pharmaceutical “drug-like leads” has gained considerable interest.1,2 By accelerating the synthesis and screening of an ever larger number of synthetic analogues, combinatorial chemistry has greatly impacted the drug discovery process.3 Despite this success, compounds originating from nat...
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Amino-substituted biphenyls were obtained by Suzuki cross-coupling of 2,6-dibromoaniline with a phenylboronic acid (substituted with Me, NO(2), OH, OMe or Cl) preferably assisted by microwave irradiation. Conversion of the amino group into a thiol preceded a base-induced intramolecular substitution, also facilitated by microwave heating, to generate the second C-S bond of the target dibenzothio...
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Cross-linked resin-captured palladium (XL-QPPd) was readily prepared by simple physical adsorption onto the high loading QuadraPure macroporous resin and a subsequent reduction process. To enhance the mechanical stability, entrapped palladium nanocatalysts were cross-linked with succinyl chloride. Both transmission electron microscopy images and X-ray diffraction analysis revealed that the pall...
متن کاملSynthesis of [6.6]Metacyclophane via the Suzuki Coupling.
Cyclophane chemistry has contributed greatly to the understanding of fields as varied as molecular and cationic recognition to fundamental principles of NMR.2 To date, the largest all-carbon [n.n]metacyclophane prepared is [5.5]metacyclophane, which was synthesized by the acid-catalyzed dimerization of δ-2-methoxyphenylvaleric acid, yet no conformational information is available about this syst...
متن کاملSynthesis of 2-C-substituted benzothiazoles via a copper-promoted domino condensation/S-arylation/heterocyclization process.
Two series of extremely useful 2-C-substituted benzothiazoles containing gem-bisphosphonates and aryl-substituted nitriles were synthesized here via a copper-promoted domino condensation/S-arylation/heterocyclization process.
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ژورنال
عنوان ژورنال: Tetrahedron Letters
سال: 2007
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2007.10.119